Stress & Cortisol Panel (Essential) | 10-Test Core Stress Investigation | Epicentre
Specialty screening · Stress and cortisol

The core check on how stress is affecting you

A focused panel measuring cortisol with the main systems stress disrupts: your thyroid, blood sugar, inflammation and key nutrients. The essential version of our stress investigation.

No doctor's referral 10 markers Fasting required Results in 2 to 5 days
Essential panel · core version
R2,750
Core stress investigation. Payflex available, about R688 a month over four payments.
10markers
Fastingrequired
2 to 5day results
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No referral. Best as a morning, fasted appointment.

Medically reviewed by Dr Samantha Naidoo, MB ChB, FCP (SA), Medical Director. Reviewed 2 June 2026.
Quick and flexible

How would you like to get tested?

Walk in

No appointment needed. Come through any branch, Monday to Friday, 08:30 to 16:00.

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Not sure which tests you need? Message us on WhatsApp and we will help you decide.

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25 yrs
Open since 2001
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Tests done
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What's tested

What does the Essential panel measure?

Ten core markers covering cortisol and the main systems stress affects. All from one morning, fasted blood draw.

Why the timing matters: cortisol follows a daily (circadian) rhythm. It is highest in the first hour after waking and falls to its lowest around midnight, so a morning fasted sample is the standard reference point. That is why this panel is best taken first thing.

Stress and adrenal hormones

Cortisol (morning fasting), DHEA-S. The core stress read: cortisol with DHEA-S, the adrenal hormone it works against.

Thyroid

TSH, Free T4. Cortisol affects thyroid function, so we check the thyroid alongside it.

Blood sugar

Fasting Glucose, HbA1c. Cortisol pushes blood sugar up; these show whether stress is shifting your metabolism.

Inflammation and blood

CRP, Full Blood Count (FBC). A marker of the inflammation stress drives, with a full blood count for overall health.

Nutrients stress depletes

Magnesium, Vitamin D. Two of the nutrients stress burns through fastest, and which deepen the cycle when they run low.

Want more detail? Step up to the Comprehensive Stress Panel: it adds hormones, metabolism, organ and vitamin markers (19 in total). See the Comprehensive Stress Panel →
Compare options

Which stress panel is right for you?

PanelWhat you getPrice
EssentialYou are viewing10 core stress and cortisol markersR2,750
Comprehensive19 markers: hormones, metabolism, organsR4,950View →
How it works

Three steps, no GP needed

1

Book a morning slot

Reserve a morning time at your branch, or walk in. No doctor's referral. Come fasted.

2

Quick blood draw

A nurse takes a small sample, just a few minutes. Morning and fasted gives the truest cortisol read.

3

Results in 2 to 5 days

A colour-coded report by marker, with a free certificate you can share with your doctor.

When this helps

Who is this panel for?

Most useful if you have been under sustained pressure and want to see whether it is showing up in your body.

Burnout or chronic stress

Months of deadlines, pressure or caregiving, and you want to know the toll it is taking.

Tired but wired

Exhausted through the day yet unable to switch off or sleep properly at night.

Brain fog and low mood

Foggy thinking, a flatter mood or a shorter fuse than usual.

Stalled recovery

Training or eating well but not recovering, with stubborn weight around the middle.

Low energy or libido

Persistent fatigue, or a drop in drive and motivation you cannot explain.

A functional baseline

You want the full cortisol-and-cascade picture to work from with a practitioner.

From our patients

What people say

★★★★★ 4.7 / 5 based on verified Google reviews
★★★★★

Friendly and competent staff. Both at reception and the nurse. A much simpler process than going through doctors. Thank you ladies.

A
Agata G.
Parktown North · 3 months ago
★★★★★

The staff at reception as well as the nurses are friendly and professional. I've also always received results timeously. I would give 10 stars if I could.

A
Abedah M.
Parktown North · Local Guide · 3 weeks ago
★★★★★

Highly highly highly recommend. The experience was painless and the practice was inviting and well kept. The report was extremely detailed and informative and I would have this as top of my list for preventive care.

N
Nadia P.
Observatory · 8 months ago
★★★★★

Amazing experience, highly professional staff. Very reasonable prices. Highly recommend.

C
Caitlin C.
Observatory · 1 year ago
★★★★★

I cannot recommend Juliette and her team enough, friendly and kind from the get go. Bloods were drawn with minimal discomfort and the labs came back quickly.

L
Laura S.
Hillcrest · 1 month ago
★★★★★

Excellent experience at Epicentre. The staff were professional, kind, and took time to explain everything clearly. The facility was clean, booking was easy, and I did not feel rushed.

A
Aaron R.
Hillcrest · 1 month ago

What this panel does not do

This is a screen that shows whether stress is leaving a measurable mark on your body. It is a starting point for a conversation, not a diagnosis.

  • A single morning cortisol is a snapshot, not a full day's rhythm or a saliva curve.
  • It does not diagnose conditions such as Cushing's or Addison's on its own; unusual results are followed up with your doctor.
  • It does not measure or diagnose a mental-health condition; it looks at the physical systems stress affects.
  • Results are meant to inform a discussion with a registered practitioner who can read them alongside your history.
Common questions

Quick answers

Cortisol (morning fasting), DHEA-S, TSH, Free T4, Fasting Glucose, HbA1c, CRP, Full Blood Count (FBC), Magnesium and Vitamin D. The panel is R2,750, with Payflex available at about R688 a month over four payments.
Yes. This panel requires fasting, and the cortisol sample is best taken in the morning. Come in the morning after an overnight fast. Water is fine, and keep to your usual medicines unless your doctor advises otherwise.
Cortisol follows a daily rhythm and is highest in the early morning. A morning fasting sample is the standard reference point, so it gives the most meaningful read of your stress response.
No. Book or walk in to any branch in Cape Town, Durban or Johannesburg without a doctor's referral.
Typically within 2 to 5 working days, with a free results certificate you can share with your doctor.
At our three walk-in labs: Observatory in Cape Town, Hillcrest in Durban and Parktown North in Johannesburg, Monday to Friday, 08:30 to 16:00.
Where to test

Three walk-in labs

Related packages

Round out the picture

Medically reviewed by Dr Samantha Naidoo, MB ChB, FCP (SA), Medical Director at Epicentre Walk-In Labs. Reviewed 2 June 2026. Epicentre Aids Risk Management (Pty) Ltd provides diagnostic laboratory testing and does not provide diagnoses, treatment or prescriptions to the public; results are intended to inform discussions with a registered healthcare practitioner.

See what stress is doing to your body

No doctor's referral, results in 2 to 5 working days. Book a morning, fasted slot, or message us if you are not sure where to start.