The Silent Hepatitis Crisis: 3.4 Million South Africans Have Hepatitis B
If you were born in South Africa before 1995, you were never vaccinated against hepatitis B as a baby. Here the infection usually spreads in early childhood, long before anyone chooses anything about how they live. Most people carrying it have no symptoms and have never been tested. One blood test tells you whether you have it, and another tells you whether you are protected.
Were you ever vaccinated against hepatitis B?
If you were born in South Africa before 1995, almost certainly not. The hepatitis B vaccine was added to the national childhood immunisation schedule in April 1995, given at 6, 10 and 14 weeks, and there has never been a catch-up programme for anyone born before that. Private schooling, medical aid and an excellent family doctor made no difference at all. The vaccine was simply not on the schedule yet. If you were born before 1995 in South Africa and have never been tested, you are exactly the person this test is for.
That matters because of how hepatitis B actually spreads in this country. The main route has not been sex or needles. It has been ordinary contact between young children, with most infections happening before the age of five, alongside transmission from mother to child around birth. An infection picked up at three years old in 1987 becomes lifelong far more often than one caught in adulthood, and it produces no symptoms for decades.
And if you were born after 1995? Being on the schedule is not the same as being protected. Recorded coverage stayed below 90 per cent for two decades after the vaccine was introduced, so some people never completed the course. Protection can also fade with time: in a study of health-care students at a South African university, 56 per cent had hepatitis B surface antibody levels below the protective threshold before they were given a booster dose.
How many South Africans have hepatitis B?
National Department of Health viral hepatitis guidelines put the hepatitis B surface antigen prevalence at about 6.7 per cent of the population, which works out to roughly 3.4 million people. That places South Africa among the highest burden countries in the world.
The infection is common here and detection is rare almost everywhere. The World Health Organization's Global Hepatitis Report 2026 found that of the 240 million people living with hepatitis B in 2024, only 27 per cent had been diagnosed and fewer than 5 per cent were receiving treatment. The same report found that deaths from hepatitis B rose 17 per cent between 2015 and 2024, which it attributes to limited diagnosis and treatment. That gap, between how many people have it and how many know, is the crisis.
What does staying undiagnosed actually cost?
Two things, and both are avoidable. The first is your liver. Untreated chronic hepatitis B causes slow scarring that can progress to cirrhosis and liver cancer, often with no warning until the damage is advanced. Found early, it can be monitored and managed by a doctor. Found late, the options narrow considerably.
The second is everyone around you. Hepatitis B spreads far more easily than HIV through sexual contact, and also through blood, shared razors or toothbrushes, and from mother to child at birth. Someone who does not know they carry it cannot take the steps that protect a partner, and cannot tell a doctor during pregnancy so that a newborn can be protected in time. A diagnosis is not only about you.
We are often asked whether you can get hepatitis B from a tattoo parlour or nail salon. Yes, if equipment that has touched blood is reused without being properly sterilised between clients.
Who should test for hepatitis B?
The short answer is anyone who has never been tested, once. These are the reasons it matters more, and the first few apply to a very large number of ordinary South Africans.
You do not need to fit a category to be worth testing. Most of the 3.4 million did not think they were at risk either.
Which test do you need?
How much does a hepatitis B blood test cost in South Africa? At Epicentre the Hepatitis B and C Panel is R538 and the surface antibody test is R400. Two questions, two tests. Pick the one that sounds like yours.
| Your question | What we test | Price | Book |
|---|---|---|---|
| “Do I have hepatitis B?” | Hepatitis B and C Panel. HBsAg, the surface antigen test, plus hepatitis C antibody in one blood draw. Results in 2 to 5 days. Payflex from about R135 a month. | R538 | Book the R538 panel |
| “Am I still protected?” | Hepatitis B surface antibody. anti-HBs, the immunity test, which shows whether your childhood vaccination still protects you. Results in 2 to 5 days. | R400 | Book the R400 test |
Not sure which? Ask for both at the same appointment. One blood draw, both answers. Already booked for a wellness or full-body panel? Either can be added to that draw. Walk in for a hepatitis B blood test in Cape Town (Observatory), Johannesburg (Parktown North) or Durban (Hillcrest), and your results come to you by email.
What happens if your result is positive?
It is not the emergency it feels like in the moment. Hepatitis B found early is a condition to be monitored and managed, and knowing puts you in a far better position than not knowing.
Take your result to a doctor
Epicentre is a diagnostic laboratory. We run the tests and give you the results; we do not provide treatment. A doctor will assess your liver and decide what monitoring or care you need.
Complete the picture with a hepatitis D test
Hepatitis D only occurs in people who already have hepatitis B, and it makes the illness considerably more serious. World Health Organization guidance published in 2024 recommends testing everyone who is HBsAg positive for it. South Africa's own national guidelines note that hepatitis D serology is not routinely available here and usually means a referral to tertiary care, so we offer the hepatitis D antibody test directly. Ask us for the current price when you book.
Let the people close to you know
Partners and household members can be tested, and those who are not infected can be vaccinated through a GP or clinic. This is how a single diagnosis stops a chain of transmission.
Frequently asked questions
Was I vaccinated against hepatitis B as a child in South Africa?
Only if you were born from 1995 onwards. South Africa added the hepatitis B vaccine to its childhood immunisation schedule in April 1995, given at 6, 10 and 14 weeks, and there has never been a catch-up programme for people born before that. If you were born before 1995 in South Africa, you almost certainly received no hepatitis B vaccine as a baby, whatever your family could afford at the time.
Does hepatitis B vaccine protection wear off?
It can. Protection from childhood vaccination is long lasting for most people, but not everyone, and recorded coverage in South Africa stayed below 90 per cent for two decades after the vaccine was introduced, so some people were never fully vaccinated in the first place. In one study of health-care students at a South African university, 56 per cent had hepatitis B surface antibody levels below the protective threshold before being given a booster. Assuming you are covered because you were vaccinated as a baby is not safe. A hepatitis B surface antibody test, R400 at Epicentre, settles it.
How do I know whether I am immune to hepatitis B?
Immunity is measured by a hepatitis B surface antibody test, written as anti-HBs. This is a different test from the HBsAg test, which shows whether you currently have hepatitis B rather than whether you are protected against it. Epicentre offers the hepatitis B surface antibody test at R400, with no doctor's referral, so if you want to know whether your childhood vaccination is still protecting you, that is the test to ask for.
Can raised liver enzymes be caused by hepatitis B?
Yes. Chronic hepatitis B is one of the causes of raised ALT or AST on a liver function test, and it is easy to miss in someone who drinks little or nothing and looks well. Fatty liver, medication, alcohol and several other conditions can also raise these enzymes. If your liver results came back abnormal, a hepatitis B and C blood test is a reasonable next step, and a doctor should interpret the full picture.
Does a standard wellness or full-body blood panel include hepatitis B?
Usually not. Most annual wellness panels and full-body health checks cover liver enzymes, cholesterol, glucose, thyroid and related markers, but they do not include a hepatitis B surface antigen test. A normal wellness report therefore does not rule out hepatitis B. It has to be requested as its own test.
Can you get hepatitis B from a tattoo, piercing or nail salon?
Yes, if equipment that has touched blood is reused without proper sterilisation. Hepatitis B survives outside the body far longer than many people expect, so tattooing, piercing, and cosmetic or nail procedures carry a risk wherever instruments are not properly sterilised between clients. Reputable studios that use single-use needles and sterilised equipment are a much lower risk.
Can you get hepatitis B without having sex?
Yes, and in South Africa that is the usual story. The main route of transmission here has been spread between young children, with most infections happening before the age of five, along with transmission from mother to child around birth. Hepatitis B also passes through blood, shared razors or toothbrushes, reused needles and unsterilised equipment. A hepatitis B diagnosis says nothing about how somebody has lived.
Is hepatitis B an STI?
It can be sexually transmitted, and it passes through sexual contact more easily than HIV, but calling it an STI misses most of the picture in South Africa. Here the majority of infections were acquired in early childhood, either around birth or through ordinary contact between young children, long before sex was ever a factor. It also spreads through blood, shared razors or toothbrushes, and unsterilised equipment. A hepatitis B diagnosis says nothing about how somebody has lived.
Can I get hepatitis B from kissing?
Kissing is not considered a usual route of transmission. Hepatitis B is found in saliva at much lower levels than in blood, and ordinary social kissing is not regarded as a meaningful risk. The virus spreads through blood and body fluids, so the routes that matter are birth, contact between young children, sexual contact, shared razors or toothbrushes, and reused needles or unsterilised equipment.
How long can you live with hepatitis B without knowing?
Decades. Chronic hepatitis B often causes no symptoms at all for twenty or thirty years while it quietly affects the liver, which is why so many people are only diagnosed once damage has already been done. Feeling completely well is not evidence that you do not have it, and a blood test is the only way to know.
Can hepatitis B go away on its own?
It depends on when you were infected. Most healthy adults who catch hepatitis B clear it themselves within about six months and develop lifelong immunity. Infants and young children usually do not: infection acquired in early childhood becomes long term in the large majority of cases. Since most hepatitis B in South Africa was acquired in early childhood, assuming it will clear on its own is not safe.
Can hepatitis B be cured?
Chronic hepatitis B can usually be controlled and monitored rather than cured, although research into curative treatment is advancing. Hepatitis C, by contrast, is curable in most cases with a short course of treatment from a doctor. Epicentre is a diagnostic laboratory and does not provide treatment, so any decision about care belongs with your doctor. What matters from our side is that neither can be managed until it has been found.
What is the difference between hepatitis A, B and C?
Hepatitis A spreads through contaminated food and water and is usually a short illness that resolves on its own. Hepatitis B and hepatitis C spread through blood and body fluids and can both become long-term infections that quietly damage the liver. There is a vaccine for hepatitis A and hepatitis B, but not for hepatitis C. Our full guide to viral hepatitis in South Africa covers each type in detail.
What does an HBsAg positive result mean?
HBsAg stands for hepatitis B surface antigen. A positive result means the hepatitis B virus is present in your blood at the time of testing. It does not tell you on its own whether the infection is recent or long standing, or how much your liver has been affected, so a doctor will usually arrange further tests to establish that. It is not an emergency, but it does need medical follow-up.
What is the difference between HBsAg and anti-HBs?
HBsAg, the surface antigen, is part of the virus itself, so a positive result means you currently have hepatitis B. Anti-HBs, the surface antibody, is made by your immune system, so a positive result means you are protected, either from vaccination or from clearing a past infection. They answer opposite questions, and a negative HBsAg result does not mean you are immune. Epicentre offers both: HBsAg within the Hepatitis B and C Panel at R538, and the surface antibody test at R400.
Which hepatitis B test do I need?
It depends on your question. If you want to know whether you currently have hepatitis B, you need the surface antigen test, HBsAg, which Epicentre runs alongside a hepatitis C antibody test in the Hepatitis B and C Panel at R538. If you want to know whether your childhood vaccination still protects you, you need the surface antibody test, anti-HBs, at R400. If you want both answers, they can be taken from the same blood draw. Neither requires a doctor's referral.
How many South Africans have hepatitis B?
National Department of Health viral hepatitis guidelines estimate a hepatitis B surface antigen prevalence of about 6.7 per cent, which works out to roughly 3.4 million people. That makes South Africa one of the highest burden countries in the world. The figure is the accepted national estimate rather than a fresh nationwide measurement, so treat it as an order of magnitude rather than an exact count.
Do I need to fast for a hepatitis B test?
No. The hepatitis B blood test needs no fasting and no preparation, so you can walk in and have it done at any time of day. If you are combining it with a wellness or metabolic panel, some of those markers do require fasting, so check when you book.
Do I need a doctor's referral to test for hepatitis B?
No. Epicentre is a walk-in laboratory, so you can book a hepatitis B and C blood test yourself with no doctor's referral, at branches in Cape Town, Johannesburg and Durban. The Hepatitis B and C Panel is R538, results come back by email in 2 to 5 days, and students and pensioners get 10 per cent off.
What happens if my hepatitis B test is positive?
Take your result to a doctor, who will assess your liver and decide what monitoring or care you need. Epicentre is a diagnostic laboratory and does not provide treatment. We can run the follow-up test that World Health Organization guidance recommends for anyone who is HBsAg positive, the hepatitis D antibody test, because hepatitis D only occurs in people who already have hepatitis B and makes the illness more serious.
Sources for the figures on this page.
People born before 1995, when routine infant hepatitis B vaccination began, being more likely to have hepatitis B: Hepatitis B prevalence and risk factors among adults living with HIV in South Africa, a clinic-based cohort study.
Hepatitis B vaccine introduced into the South African Expanded Programme on Immunisation in April 1995 at 6, 10 and 14 weeks: Vaccine, first five years of universal hepatitis B vaccination in South Africa. No catch-up programme, and transmission occurring mainly between young children before the age of five: An update after 16 years of hepatitis B vaccination in South Africa and The role of new hepatitis B vaccines in South Africa.
Recorded vaccine coverage below 90 per cent in the two decades after introduction, and 56 per cent of health-care students non-immune before a booster dose: Hepatitis B virus immunity before and after a booster dose among health-care students at a South African university.
Prevalence of 6.7 per cent and about 3.4 million people: South African National Department of Health, National Guidelines for the Management of Viral Hepatitis, which states that South Africa has one of the largest hepatitis B burdens globally with an estimated HBsAg prevalence of 6.7 per cent, or 3.4 million individuals.
Proportion of people with hepatitis B diagnosed and treated worldwide, and the 17 per cent rise in hepatitis B deaths between 2015 and 2024: World Health Organization, Global Hepatitis Report 2026, published 28 April 2026.
Hepatitis B prevalence of 11.24 per cent among pregnant women: Hepatitis B infection status among women attending antenatal care at public healthcare facilities of South Africa, 2017, PLOS Global Public Health, which tested samples collected during the 2017 national antenatal sentinel survey and called for a universal birth dose of the hepatitis B vaccine.
Reflex hepatitis D testing for people who are HBsAg positive: World Health Organization hepatitis B guidelines, 2024. South Africa's national viral hepatitis guidelines do cover hepatitis D, but note that hepatitis D serology is not routinely available and advise referral to tertiary level care. Testing everyone who is HBsAg positive is international best practice that we have adopted, rather than current South African national policy.
This article is general health information and not medical advice. Epicentre is a diagnostic laboratory: we provide testing and results, and we do not diagnose or treat. Please discuss any result with a doctor. If you have jaundice, severe abdominal pain or you are vomiting blood, seek medical care immediately.
