Fatigue Blood Tests | Tired All the Time? | Epicentre
FatigueEnergy

Tired all the time? Find out why

Blood tests to uncover the cause of your fatigue. Iron, thyroid, vitamins, hormones, cortisol, blood sugar. Most unexplained tiredness has a cause you can find and treat. A blood test takes 15 minutes.

4.5/5 Google RatingNo doctor's referralResults in 2 to 5 working daysMost causes treatable

Find the right test for your tiredness

Tell us what your tiredness feels like and we'll point you to the panel that checks the most likely causes, with how to prepare.

Question 1 of 2

What does your tiredness feel like?

This helps you choose a test. It isn't a diagnosis. If you're unsure, WhatsApp us your symptoms and we'll help.

The usual culprits

What causes constant tiredness?

Fatigue is a symptom, not a diagnosis. These six causes are behind most unexplained tiredness, and every one is simple to check with a blood test.

Up to 1 in 5SA women of reproductive age

Low iron

Low iron means less oxygen reaching your cells. The most common cause in women.

About 1 in 10adults, more often women

Thyroid trouble

A slow thyroid slows your metabolism and saps energy, often quietly for years.

Up to 2 in 5adults in SA studies

Low vitamin D

Yes, even here. Low vitamin D drags down energy, mood and immunity.

Commonin plant-based diets

Low vitamin B12

Essential for nerves and healthy red blood cells. Low levels cause fatigue and brain fog.

Oftenmissed

Blood sugar swings

Unsteady blood sugar can cause energy crashes and afternoon slumps.

Stressand recovery

The stress response

The body's stress response affects recovery, sleep quality and daytime energy.

Sources: Turawa et al. 2021 (South African review of iron deficiency in women), Canaris et al. 2000 (Colorado thyroid disease prevalence study), Eastern Cape healthcare workers study 2024 (vitamin D).

15 min
is all a blood test takes. Most unexplained tiredness has a cause you can find and treat, and the hard part is knowing which one.

Fatigue testing packages

Start simple with iron and thyroid. Go comprehensive if you want answers fast. All packages include a plain-language Functional Health Report, produced using Optimal DX, plus the standard lab report for your doctor.

Start here

Vegetarian and Vegan Panel

R2,514

Nine tests for the nutrients most often low on a plant-based diet: B12, iron studies, vitamin D, zinc, magnesium and calcium, plus a full blood count, cholesterol and kidney function. Fasting required, 8 to 12 hours, water only.

Vitamin B12Iron StudiesVitamin DZincFBCMagnesiumCalciumLipogramCreatinine
Comprehensive

Vital Health Package

R3,200

Thirteen markers covering the core fatigue causes in one panel: iron stores, thyroid, vitamin D, B12, blood sugar, cholesterol, liver, kidney, inflammation and a full blood count. Checks the most common blood causes of fatigue in one visit. Fasting required, 8 to 12 hours, water only.

Glucose FastingHbA1cFerritinTSHFree T4Vitamin D3Vitamin B12CRPFBCLipogramLFT PanelU&E and ElectrolytesLDH

Max Health Package

R5,231

Twenty-one markers for the most thorough fatigue investigation: cortisol, full thyroid (TSH, free T4, free T3), oestrogen and testosterone, blood sugar and fasting insulin, iron, B12, vitamin D, homocysteine, calcium, magnesium, phosphate, uric acid, cholesterol, liver, kidney and a full blood count. Morning draw, book before 10am. Fasting required, 8 to 12 hours, water only.

Cortisol SerumTSHFree T4Free T3OestrogenTestosterone (Total)Glucose FastingHbA1cInsulin FastingIronVitamin B12Vitamin D3HomocysteineMagnesium+7 more
Targeted

Mental Health and Mood Panel

R3,973

Thirteen markers behind mood, focus and mental energy: cortisol, DHEA-S, free testosterone and thyroid, with fasting insulin, iron, vitamin D, B12, folate, homocysteine, magnesium, calcium and inflammation. Morning draw, book before 10am. Fasting required, 8 to 12 hours, water only.

CortisolDHEA-SFree TestosteroneTSHInsulin FastingCRPHomocysteineVitamin B12FolateVitamin DMagnesiumIron StudiesCalcium

Stress and Cortisol Panel (Essential)

R2,771

Ten markers for the wired-but-tired pattern: morning cortisol and DHEA-S, the two main stress hormones, plus thyroid, blood sugar, inflammation, magnesium, vitamin D and a full blood count. Morning draw, book before 10am. Fasting required, 8 to 12 hours, water only.

CortisolDHEA-STSHFree T4Fasting GlucoseHbA1cCRPFBCMagnesiumVitamin D

Functional Health Analysis

R4,584

Sixteen markers for nutrient and energy status: cortisol and DHEA-S, iron, folate, B12, vitamin D, magnesium, zinc, copper, calcium, homocysteine, blood sugar, liver (gamma GT), kidney, LDH and a full blood count. Morning draw, book before 10am. Fasting required, 8 to 12 hours, water only.

CortisolDHEA-SIron SerumFolateVitamin B12Vitamin DMagnesiumZincCopperCalciumHomocysteineGlucose FastingGamma GTU&E + CreatinineLDHFBC

Long COVID Assessment

R1,439

Inflammation, clotting markers and deficiencies common after COVID infection. No fasting required.

FBCESRCRPD-DimerVitamin DVitamin B12

Not sure where to start? If you are new to testing, start with the Iron and Anaemia Package plus the Thyroid Package. Together these check the two most common blood causes of tiredness. If those come back normal, move to a comprehensive panel. Or WhatsApp us and describe your symptoms.

Fasting note: Basic panels (iron, thyroid, Long COVID): no fasting required. Panels that include glucose, insulin, cholesterol or cortisol, including the Vegetarian and Vegan Panel and the comprehensive packages: fast 8 to 12 hours, water only. Panels with cortisol (Max Health, Mental Health and Mood, Stress and Cortisol, Functional Health Analysis): book before 10am.

All packages: Payflex available (4 interest-free instalments). 10% student discount. 10% pensioner discount. All prices include VAT.

Frequently asked questions

What blood tests should I get if I am always tired?
Start with iron studies (including ferritin), thyroid function (TSH, Free T4, Free T3), vitamin D and vitamin B12. These cover the most common treatable causes. If those are normal, consider a comprehensive panel including cortisol, blood sugar markers (HbA1c) and inflammation markers (CRP).
Do I need to fast?
Basic panels (iron, thyroid, Long COVID): no fasting required. Panels that include glucose, insulin, cholesterol or cortisol, including the Vegetarian and Vegan Panel and the comprehensive packages: fast 8 to 12 hours, water only. Panels with cortisol (Max Health, Mental Health and Mood, Stress and Cortisol, Functional Health Analysis): book before 10am.
How long do results take?
2 to 5 working days for all panels. Results via email: plain-language Functional Health Report plus standard lab report for your doctor.
What if my results are abnormal?
Most fatigue causes are treatable once identified. Iron deficiency, vitamin D deficiency and thyroid dysfunction all respond well to treatment. Share results with your own doctor, or Epicentre can connect you with partner physicians. Test and Treat guide.
Is ferritin the same as iron?
Serum iron measures iron in your blood right now. Ferritin measures your iron stores. You can have normal serum iron but low ferritin, meaning your reserves are depleted. Both should be tested together.
Can I test for chronic fatigue syndrome?
There is no single test for CFS/ME. However, comprehensive blood work rules out other causes (thyroid, iron, vitamin deficiencies, blood sugar problems, inflammation) which is the first step in any CFS investigation.

Stop guessing. Start testing.

Most unexplained tiredness has a cause you can find and treat. A blood test takes 15 minutes. No doctor's referral.

Walk-in labs: Observatory (Cape Town), Hillcrest (Durban), Parktown North (Johannesburg). Mon to Fri, 08:30 to 16:00. Practice #1117394.

Epicentre Walk-In Labs does not provide medical diagnoses. For diagnoses and advice, consult your healthcare practitioner.